China (Mainland)
High quality Nicotinamide CAS NO. 98-92-0 CAS NO.98-92-0
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- Product Details
Keywords
- nicotinamide
- 98-92-0
- nicotinamide 99%
Quick Details
- ProName: Nicotinamide
- CasNo: 98-92-0
- Molecular Formula: C6H6N2O
- Appearance: White crystalline powder
- Application: High quality Nicotinamide/CAS NO. 98-9...
- DeliveryTime: 2-3 days after payment
- PackAge: (1). 1-10kg / foil bag (2). 25kg / d...
- Port: SHANGHAI
- ProductionCapacity: 1000 Kilogram/Month
- Purity: 99%
- Storage: Store in cool & dry place
- Transportation: 1.Air Courier Express Door to Door Ser...
- LimitNum: 1 Kilogram
- Related Substances: <0.1%
- Residue on Ignition: <0.1%
- Heavy Metal: <1ppm
- Valid Period: 24 months
Superiority
| Nicotinamide Basic information |
| Product Name: | Nicotinamide |
| Synonyms: | 3-PYRIDINECARBOXAMIDE;3-PYRIDINE CARBOXYLIC ACID AMIDE;3-PYRIDINECARBOXYLIC AMIDE;TIMTEC-BB SBB004283;NICETHAMIDUM;NIACINAMIDE;NICOTINIC ACID AMIDE;NICOTINAMIDE |
| CAS: | 98-92-0 |
| MF: | C6H6N2O |
| MW: | 122.12 |
| EINECS: | 202-713-4 |
| Product Categories: | Inhibitors;Pharmaceutical intermediates;Biochemistry;Vitamins;Nutritional Supplements;Vitamins and derivatives;Vitamin Ingredients;Miscellaneous Compounds;Aromatics;Nicotine Derivatives;Vitamin series;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;vitamin;Other;Cosmetics;food additive;Cosmeitc raw materials |
| Mol File: | 98-92-0.mol |
| Nicotinamide Chemical Properties |
| Melting point | 128-131 °C(lit.) |
| Boiling point | 150-160 °C |
| density | 1.40 |
| Fp | 182 °C |
| storage temp. | 0-6°C |
| solubility | 691g/l |
| pka | 3.3(at 20℃) |
| form | powder |
| color | white |
| PH | 6.0-7.5 (50g/l, H2O, 20℃) |
| Water Solubility | 1000 g/L (20 ºC) |
| Merck | 14,6523 |
| BRN | 383619 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | DFPAKSUCGFBDDF-UHFFFAOYSA-N |
| CAS DataBase Reference | 98-92-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Niacinamide(98-92-0) |
| EPA Substance Registry System | 3-Pyridinecarboxamide(98-92-0) |
| Safety Information |
| Hazard Codes | Xi,T,F |
| Risk Statements | 36/37/38-39/23/24/25-23/24/25-11 |
| Safety Statements | 26-36-37/39-45-36/37-16-7 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 1 |
| RTECS | QS3675000 |
| F | 8 |
| TSCA | Yes |
| HS Code | 29362990 |
| Hazardous Substances Data | 98-92-0(Hazardous Substances Data) |
| MSDS Information |
| Provider | Language |
|---|---|
| 3-Pyridinecarboxamide | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| Nicotinamide Usage And Synthesis |
| description | Nicotinamide is also called vitamin B3 or vitamin PP, is a kind of water-soluble vitamin, belong to B vitamin, as NAD (nicotinamide adenine dinucleotide, NAD) and NADP (nicotinamide adenine dinucleotide phosphate, NADP) composition, hydrogenation and dehydrogenation properties of nicotinamide in the body part of this two kinds of structure of coenzyme the reversible, play a role of hydrogen delivery in biological oxidation, can promote tissue respiration, biological oxidation process and the new supersedes the old, having a great significance in maintaining normal tissue, especially the integrity of the skin digestive tract and the nervous system. When the lack of B vitamins, due to respiration and metabolism of cells affected by pellagra, so this product is mainly used for the prevention and treatment of pellagra, stomatitis, glossitis and so on. In addition, this product has prevention of heart block and improving the sinoatrial node and anti-fast experimental arrhythmia function, can significantly improve Vera Pammy induced bradycardia and atrioventricular block. The clinical for coronary heart disease, viral myocarditis, rheumatic heart disease and a handful of digitalis poisoning associated with arrhythmia (mostly applied only when other medications fail), generally the degree atrioventricular block has obvious curative effect, basically after the treatment, all block can disappear, has obvious curative effect in sick sinus syndrome, right bundle branch block effect is poor. After the stomach intestinal absorption by the oral, intramuscular absorption faster, then absorption distribution to the body tissues, t1/2 is 45 min. The liver metabolism, most metabolize N-n-methylnicotinamide, only a small amount of treatment as the prototype from the urine was more than necessary. If the daily urinary excretion of N-methyl nicotinamide is lower than 4mg, suggesting that nicotinamide deficiency. Nicotinamide and nicotinic acid are collectively referred to vitamin PP, nicotinic acid in the animal body is involved in metabolic processes in the form of nicotinamide, both have a common vitamin activity. It is white crystalline powder, odorless or almost odorless, bitter taste, easily soluble in water or ethanol, soluble in glycerol. Hygroscopic weak stable., acid, alkali and high temperature. The nature mainly exists in cereal skin, yeast, peanuts, meat, animal organs, milk and green leafy vegetables, in the body it is from tryptophan synthesis, but the efficiency is very low. Escherichia coli in the intestine (Escherichia coli) can be converted into synthesis of nicotinic acid, nicotinamide. Prevention and treatment of pellagra, exposed parts of symmetric dermatitis, stomatitis, glossitis, anorexia, dermatitis, liver disease, coronary heart disease, atrioventricular block, sick sinus syndrome, diarrhea, neuritis and dementia. [Adverse reaction] Occasionally dizziness, nausea, abdominal discomfort, loss of appetite, disappear on their own, in early pregnancy overdose possible teratogenic intramuscular injection can cause pain, so less. The above information is Chemicalbook Hanya edited. |
| Chemical Properties | It is white needle crystal or crystalline powder, no smell or odor slightly, slightly bitter taste. The relative density is 1.4, melting point is 131-132 ℃.1 g of the above the product is soluble in 1 ml of water, 1.5 ml ethanol or 10 ml glycerin, insoluble in ether. The pH of 10% aqueous solution is 6.5-7.5. in dry air to light and heat stability, in alkaline or acidic solution, heating generation to nicotinic acid. Rats by oral LD502.5-3.5g/kg ADI value does not make special provisions (ECC, 1990) |
| Uses | Same as nicotinic acid. Water soluble is better than niacin acid, easy to generate complex agglomerate with vitamin C. The dosage is 30-80 mg/kg. Nicotinamide and nicotinic acid are in common use generally and nicotinic acid can transform into nicotinamide in animals. Lack of nicotinic acid and nicotinamide, results in pellagra. So they can prevent pellagra. They also play a role in the metabolism of protein and sugar, which can improve human and animal nutrition. In addition to be used as a medicine, it can also be applied in food and feed additives. The production capacity is more than 30000 tons in the world. In Japan, niacinamide used in medicine (40%), feed additives (50%) and food additives (10%). Nicotinic acid and nicotinamide are non-toxic, naturally contains in liver, kidney, yeast and honey. The niacinamide LD50 of subcutaneous injection for rat is 1.7 g/kg. It is of Vitamin drugs, and involved in metabolic process. Can be used in skin care products, to prevent coarse skin, maintain healthy skin cells, and promote skin whitening. In addition, it can also be used in hair care products, to promote scalp blood circulation, healthy hair follicles, promotes hair growth and prevent alopecia. Used in biochemical research. To prepare tissue culture medium. The pharmaceutical industry. |
| Toxicity | LD50 2.5~3.5 g/kg (rats, through the mouth). GRAS(FDA，§182.5535，2000). ADI is no special regulation (EEC, 1990). |
| Synthesis | 1.β-methyl pyridine is oxidized to nicotinic acid by air, and the latter is produced by the action of ammonium hydroxide, and then heating and dehydration. 2.Nicotinic acid, boric acid and ammonia into reaction pot, stirring at the condition of ammonia gas, heating dissolution; then distilled ammonia recovery, to 120℃ after the immigration dewatering pot continues to enrich; when the temperature reached 145 ℃, start adding liquid ammonia, and in 185 to 190℃ to ammonia reaction 20～30h. And then cooled to 130℃, diluted with distilled water, activated carbon was added, and in 70~80℃through ammonia decolorization 2h; reaction after filtered, , filtrate in 24 hours after analysis of cold water, fractional crystallization and washing with ethanol, and drying to obtain the finished product. The yield was 89%. 3. From the nicotinic acid and ammonia react into salt and then dehydrated. |
| Chemical Properties | White crystalline powder |
| Uses | Niacinamide USP is used as food additive, for multivitamin preparations and as intermediate for pharmaceuticals and cosmetics. |
| Uses | A water-soluble vitamin B, incorporated within nicotinamide cofactors such as NADH and NADPH. |
| Uses | Vitamin B3; enzyme cofactor; anti-pellagra |
| Definition | ChEBI: A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group. |
| General Description | White powder. |
| Air & Water Reactions | Water soluble. |
| Reactivity Profile | An amine and amide. Acts as a weak base in solution. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). |
| Nicotinamide Preparation Products And Raw materials |
| Preparation Products | Nicotinic acid-->3-Cyanopyridine-->3-Aminopyridine-->Nicosulfuron-->Enoxacin-->2-Aminosulfonyl-N,N-dimethylnicotinamide-->4-(3-AMINOPROPYL)-2,4-DIHYDRO-3H-PYRAZOL-3-ONE-->Diflufenican-->Nicotinamide-N-oxide-->NIPECOTAMIDE-->3-Pyridinecarboxylic acid N-hydroxymethylamide |
| Raw materials | Ammonium hydroxide-->Ammonia-->4-Chlorobenzaldehyde-->Nicotinic acid-->3-Cyanopyridine-->3-Picoline |
Details
Quick Details
- ProName: Nicotinamide
- CasNo: 98-92-0
- Molecular Formula: C6H6N2O
- Appearance: powder
- Application: It is an important raw material and in...
- DeliveryTime: prompt
- PackAge: according to the clients requirement
- Port: Shanghai
- ProductionCapacity: 1-1000 Metric Ton/Day
- Purity: 98%
- Storage: Store in dry, dark and ventilated plac...
- Transportation: by sea or by air
- LimitNum: 1 Gram
Same as nicotinic acid. Water soluble is better than niacin acid, easy to generate complex agglomerate with vitamin C. The dosage is 30-80 mg/kg.
Nicotinamide and nicotinic acid are in common use generally and nicotinic acid can transform into nicotinamide in animals. Lack of nicotinic acid and nicotinamide, results in pellagra. So they can prevent pellagra. They also play a role in the metabolism of protein and sugar, which can improve human and animal nutrition. In addition to be used as a medicine, it can also be applied in food and feed additives. The production capacity is more than 30000 tons in the world. In Japan, niacinamide used in medicine (40%), feed additives (50%) and food additives (10%). Nicotinic acid and nicotinamide are non-toxic, naturally contains in liver, kidney, yeast and honey. The niacinamide LD50 of subcutaneous injection for rat is 1.7 g/kg.
It is of Vitamin drugs, and involved in metabolic process. Can be used in skin care products, to prevent coarse skin, maintain healthy skin cells, and promote skin whitening. In addition, it can also be used in hair care products, to promote scalp blood circulation, healthy hair follicles, promotes hair growth and prevent alopecia.
Used in biochemical research. To prepare tissue culture medium. The pharmaceutical industry.
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