Spirolactone / spironolactone CAS 52-01-7 CAS NO.52-01-7
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- Min.Order: 1 Kilogram
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- Available Specifications:
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- Product Details
Keywords
- Spirolactone
- spironolactone
- CAS 52-01-7
Quick Details
- ProName: Spirolactone / spironolactone CAS 52-0...
- CasNo: 52-01-7
- Molecular Formula: C24H32O4S
- Appearance: Off white crystalline powder
- Application: pharmaceutical industry
- DeliveryTime: 2-3 days after payment
- PackAge: (1). 1-10kg / foil bag (2). 25kg / d...
- Port: SHANGHAI
- ProductionCapacity: 1000 Kilogram/Month
- Purity: 99%
- Storage: Store in cool & dry place
- Transportation: 1.Air Courier Express Door to Door Ser...
- LimitNum: 1 Kilogram
- Related Substances: <0.1%
- Residue on Ignition: <0.1%
- Heavy Metal: <1ppm
- Valid Period: 24 months
Superiority
1.high purity
2.consistent quality
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4.fast shipping
Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products raw materials. Binbo is engaged in R&D with perfect equipments and advanced detecting instruments. The factory is in strict accordance with GMP standard in the course of design and construction.
Details
spironolactone (inn, ban, usan) commonly referred to simply as spiro, and marketed primarily under the brand name aldactone in most countries, is a synthetic, steroidal antimineralocorticoid and antiandrogen that also has some weak progestogen properties, as well as some indirect estrogen and glucocorticoid effects. it is used primarily as a diuretic and antihypertensive, but may also be employed for the purpose of reducing elevated or unwanted androgen activity in the body. it acts predominantly as an antagonist of the mineralocorticoid (or aldosterone) and androgen receptors, and in relation to its antimineralocorticoid effects, belongs to a class of pharmaceutical drugs known as potassium-sparing diuretics.
spironolactone is used primarily to treat heart failure, edematous conditions such as nephrotic syndrome or ascites in patients with liver disease, essential hypertension, hypokalemia, secondary hyperaldosteronism (such as occurs with hepatic cirrhosis), and conn's syndrome (primary hyperaldosteronism). on its own.
because spironolactone reduces the body's production of testosterone and blocks the androgen receptors, it can cause effects associated with low testosterone levels and hypogonadism in males. for this reason, men are typically not prescribed spironolactone for any longer than a short period of time, e.g. for an acute exacerbation of heart failure. the newer drug, eplerenone has been approved by the u.s. food and drug administration for treatment of heart failure, but lacks the rather potent antiandrogen effects and thus is far more suitable for men for whom long term medication is being chosen. unlike with some other diuretics, potassium supplementation should not be administered while taking spironolactone as this may cause dangerous elevations in serum potassium levels resulting in hyperkalemia and potentially deadly cardiac arrythmias. physicians must be careful to monitor potassium levels in both males and females who are taking spironolactone, especially during the first twelve months of use and whenever the dosage is increased.
test items |
specification |
test results |
appearance |
white or almost white crystalline powder |
white crystalline powder |
loss on drying |
≦0.5% |
0.34% |
melting point |
139-141 °c |
139-140 °c |
(hplc)assay |
97-103.0% |
99.08% |
free acid |
0.5%max |
0.31% |
conclusion |
the aboye product conforms analysis standard |
conform |
It can be used as a kind of inefficient diuretic drugs.
It is a synthetic 17-lactone steroid which is a kind of renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension and hypokalemia.
The active metabolite of lactone (spironolactone); It can be used for the Inhibition of aldosterone biosynthesis. It can also be used as the blocker of the Quabain effect.
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Binbo Biological Co., Ltd. is located in the convenient transportation and beautiful scenery of Jining high-technology industrial zone - Jinxiang economic Development Zone. There is a 105 National road links north and south when Zaocao and Dongfeng Roads connect east and west. Besides, provincial expressway and Ji-Xu expressway which connect Beijing,Shanghai,Fuzhou, and several cities across the JinXiang economic development zone. More importantly, there are only 20 km to Jining airport and close to Qufu high-speed railway station.These convenient geographical conditions bring the development opportunities for this economic development zone.
Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products raw materials. Company was established in 2001, currently our company has more than 28 thousand square meters covering area. Factory buildings and workshops were establishsd by modern production requirements.There are three steps of development project which planned to invest around 60 million RMB. Currently the first step were finished and spent 28 million RMB, which met the production and office requirements.
Binbo is engaged in R&D with perfect equipments and advanced detecting instruments. The factory is in strict accordance with GMP standard in the course of design and construction.
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