Binbo Biological Co., Ltd

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CAS 274901-16-5 Galvus Vildagliptin for diabetes

CAS 274901-16-5 Galvus Vildagliptin for diabetes CAS NO.274901-16-5

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Keywords

Vildagliptin
Galvus
274901-16-5

Quick Details

ProName: CAS 274901-16-5 Galvus Vildagliptin fo...
CasNo: 274901-16-5
Molecular Formula: C16H15F6N5O?H3O4P?H2O
Appearance: white fine powder
Application: pharmaceutical industry
DeliveryTime: 2-3 days after payment
PackAge: (1). 1-10kg / foil bag (2). 25kg / d...
Port: SHANGHAI
ProductionCapacity: 1000 Kilogram/Month
Purity: 99%
Storage: Store in cool & dry place
Transportation: 1.Air Courier Express Door to Door Ser...
LimitNum: 1 Kilogram
Related Substances: <0.1%
Residue on Ignition: <0.1%
Heavy Metal: <1ppm
Valid Period: 24 months

Superiority

1.high purity

2.consistent quality

3.competitive price

4.fast shipping

Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and APIs, Raw Steroid, Hormone products and other raw materials. Binbo is engaged in R&D with perfect equipments and advanced detecting instruments. The factory is in strict accordance with GMP standard in the course of design and construction.

Details

Product Name: Vildagliptin

Synonyms: Vildagliptin (NVP-LAF 237);(-)-(2S)-1-[[(3-Hydroxytricyclo[3.3.1.1[3,7]]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile;Vildagliptin;2-Pyrrolidinecarbonitrile, 1-(((3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)amino)acetyl)-, (2S)-;Galvus;Laf 237;Unii-I6B4B2U96p;Vidagliptin (see vildagliptin)

CAS: 274901-16-5

MF: C16H15F6N5O H3O4P H2O

MW: 303.4

EINECS: 1308068-626-2

Product Categories: Amines;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labelled Compounds;Metabolites & Impurities;API;Inhibitor;Galvus;Other APIs

Mol File: 274901-16-5.mol

Vildagliptin (vildagliptin), developed by Novartis (Novartis) Pharmaceutical Co., Ltd, is another oral administrated inhibitor of Dipeptidyl peptidase-IV after sitagliptin (sitagliptin). In 2008, it is approved for marketing in the European Union for the treatment of type 2 diabetes.

Diabetes is a chronic metabolic disease with its prevalence being increased year by year. Type 2 diabetes is a complicated diseases caused with the combined action between polygenic genetic factors and environmental factors.

Dipeptidyl peptidase IV (DPP-IV) inhibitors are a new class of anti-diabetic drugs which induces and facilitate the biosynthesis and secretion of insulin. It plays a role in lowering the blood carbohydrate concentration through multiple mechanisms such as inhibiting the β cell apoptosis, inhibiting glucagon secretion and reducing food intake. During its lowering effect on reducing blood carbohydrate levels, it can also reverse the situation of deteriorating function of pancreas islet for diabetic patients at the same time. Vildagliptin is the representative of drugs among the dipeptidyl peptidase inhibitor. It exhibited a good anti-diabetic effects and tolerance no matter whether it is being administered alone or in combination with metformin and insulin medication in clinical studies.

product name	Vildagliptin
assay	99.0% to 101.0%	99.9%
melting point	----	----
loss on drying	0.5%max.	0.22%
sulphated ash	0.1%max.	0.05%
acidity	0.01m naoh<0.50ml	0.39

1. Vildagliptin (LAF-237) inhibits DPP 4 with IC50 of 2.3 nM

2. The major metabolite of Vildagliptin

3. Labelled Vildagliptin. It is a new oral anti-hyperglycemic agent of a new dipeptidyl peptidase-IV (DPP-IV) inhibitor class of drugs. Antidiabetic.

4. A metabolite of Vildagliptin

1. Air Courier Express Door to Door Service （DHL / TNT / FEDEX / UPS / EMS）

2. Normal Air

3. Normal Sea

Binbo Biological Co., Ltd. is located in the convenient transportation and beautiful scenery of Jining high-technology industrial zone - Jinxiang economic Development Zone. There is a 105 National road links north and south when Zaocao and Dongfeng Roads connect east and west. Besides, provincial expressway and Ji-Xu expressway which connect Beijing,Shanghai,Fuzhou, and several cities across the JinXiang economic development zone. More importantly, there are only 20 km to Jining airport and close to Qufu high-speed railway station.These convenient geographical conditions bring the development opportunities for this economic development zone.

Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products and APIs, Raw Steroid, Hormone products and other raw materials. Company was established in 2001, currently our company has more than 28 thousand square meters covering area. Factory buildings and workshops were establishsd by modern production requirements.There are three steps of development project which planned to invest around 60 million RMB. Currently the first step were finished and spent 28 million RMB, which met the production and office requirements.

Binbo is engaged in R&D with perfect equipments and advanced detecting instruments. The factory is in strict accordance with GMP standard in the course of design and construction.